Genetic markers in oligodendroglial tumours
نویسندگان
چکیده
منابع مشابه
Genetic markers in oligodendroglial tumours
BACKGROUND Oliogodendrogliomas are brain tumours composed of the cells resembling oligodendrocytes. They represent the third most common glial tumour, comprising 2.5% of all primary brain tumours and 5-20% of all gliomas. CONCLUSIONS Oligodendroglial tumours with 1p and 19q loss demonstrate a better overall prognosis due to more indolent clinical behaviour and higher sensitivity to treatment....
متن کاملTumour markers in pediatric solid tumours
Tumour marker as a term generally refers to developmentally regulated proteins which are expressed in or from neoplastic tissues. Traditionally these proteins were protein or carbohydrate molecules, which were expressed in the fetus during the developmental period, thus these were also known as ‘oncofetal antigens’. In the present era the term ‘tumour marker’ has acquired a broader sense and im...
متن کاملMolecular imaging of 1p/19q deletion in oligodendroglial tumours with 11C-methionine positron emission tomography
OBJECTIVE Chromosome 1p/19q deletion is an established prognostic and predictive marker in the WHO grade III oligodendroglial tumours (OT). To estimate the genetic status preoperatively, the authors investigated the correlation between the uptake of (11)C-methionine in positron emission tomography (PET) and the 1p/19q status in grades II and III OT. METHODS We retrospectively reviewed 144 pat...
متن کاملHistological growth patterns and genotype in oligodendroglial tumours: correlation with MRI features.
Oligodendroglial neoplasms with the -1p/-19q genotype are more indolent with longer survival and increased therapeutic responsiveness than those with intact 1p/19q, but the biological basis for these clinical differences is unclear. Recent research suggests that oligodendrogliomas with and without the -1p/-19q genotype may be distinguished by their magnetic resonance imaging (MRI) appearance, s...
متن کاملMolecular imaging of 1p/19q deletion in oligodendroglial tumours with C-methionine positron emission tomography
To cite: Iwadate Y, Shinozaki N, Matsutani T, et al. J Neurol Neurosurg Psychiatry 2016;87: 1016–1021. ABSTRACT Objective Chromosome 1p/19q deletion is an established prognostic and predictive marker in the WHO grade III oligodendroglial tumours (OT). To estimate the genetic status preoperatively, the authors investigated the correlation between the uptake of C-methionine in positron emission t...
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ژورنال
عنوان ژورنال: Radiology and Oncology
سال: 2010
ISSN: 1581-3207,1318-2099
DOI: 10.2478/v10019-010-0007-y